منابع مشابه
Nutritional hormesis and aging.
Nutritional hormesis has the potential to serve as a pro-healthy aging intervention by reducing the susceptibility of the elderly to various chronic degenerative diseases and thereby extending human healthspan. Supportive evidence for nutritional hormesis arising from essential nutrients (vitamins and minerals), dietary pesticides (natural and synthetic), dioxin and other herbicides, and acryla...
متن کاملAging, anti-aging, and hormesis.
As a result of almost 50 years of efforts in collecting descriptive data, biogerontologists are now able to construct general principles of aging and to explore possibilities of gerontomodulation. Most of the data indicate that aging is characterized by a stochastic accumulation of molecular damage and a progressive failure of maintenance and repair, and the genes involved in homeodynamic pathw...
متن کاملHormesis, cell death and aging
Frequently, low doses of toxins and other stressors not only are harmless but also activate an adaptive stress response that raise the resistance of the organism against high doses of the same agent. This phenomenon, which is known as "hormesis", is best represented by ischemic preconditioning, the situation in which short ischemic episodes protect the brain and the heart against prolonged shor...
متن کاملExercise-induced hormesis may help healthy aging.
Hormesis plays a critical role in producing some major benefits derived from physical exercise. However whether these known cellular mechanisms are applicable to ameliorate age-related deterioration of muscle function is not entirely clear. The present communication proposes that antioxidant adaptation, the peroxisome proliferator-activated receptor gamma coactivator (PGC)-1alpha activated mito...
متن کاملHormesis in Aging and Neurodegeneration—A Prodigy Awaiting Dissection
Hormesis describes the drug action of low dose stimulation and high dose inhibition. The hormesis phenomenon has been observed in a wide range of biological systems. Although known in its descriptive context, the underlying mode-of-action of hormesis is largely unexplored. Recently, the hormesis concept has been receiving increasing attention in the field of aging research. It has been proposed...
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ژورنال
عنوان ژورنال: Dose-Response
سال: 2009
ISSN: 1559-3258,1559-3258
DOI: 10.2203/dose-response.09-012.hayes